This study develops a multi-region computable general equilibrium model (CGE model) that considers limited factor movement on the regional economy of the Yangtze River Delta (YRD) in China. Broadly, the YRD is composed of Shanghai City, Jiangsu province, and Zhejiang province. Over the past three decades, the YRD has achieved remarkable economic growth; the YRD was identified as a national-level regional economic circle in the “People’s Republic of China national economic and social development 11th Five-Year Plan.” This not only reflects the region’s economic strength and its tremendous past achievements in economic development, but also highlights that it is integral to China’s future economic development. However, these regions face challenges to future economic growth. One major problem is the income inequality between rural and urban areas. The mobility of people is considered a solution to this problem. Therefore, this study analyzes this mobility with a CGE model. Input-output tables in these three regions are used to develop the model, and the factor market connects these three regions. Moreover, this model addresses the mobility of productive factors such as labor and capital. Concretely, we will assume four types of labor mobility: labor can move between regions, between industrial sectors, between regions and sectors, or it cannot move at all. This study simultaneously models these four types of labor mobility. Under these assumptions, the economic effect of each region (Shanghai City, Jiangsu province, and Zhejiang province) is analyzed.